Our Atletico Nacional Medellin vs America de Cali Prediction: 2-1
Atletico Nacional Medellin vs America de Cali in the Colombia Primera A is scheduled for an 00:30 GMT kick-off on Friday November 21, 2025. A 2-1 victory for the hosts is our top prediction, yet given both teams’ attacking form, BTTS seems like a smart betting choice.
Our prediction is supported by key Atletico Nacional Medellin vs America de Cali stats, including attacking and defensive strength, recent form and historical results — all detailed below.
→ View Today's Correct Score Predictions
Recent Form Insights
Atletico Nacional Medellin's Last Match – America de Cali vs Atletico Nacional Medellin
Atletico Nacional Medellin should win to turn things around after settling for a 2-2 Colombia Cup draw against America de Cali on November 16. In that match, Atletico Nacional Medellin recorded 50% possession, firing 13 shots at goal, with 7 on target.
| Team | Possession | Shots (on target) | xG | Dangerous Attacks |
|---|---|---|---|---|
 America de Cali | 50% | 11 (6) | - | 84 |
 Atletico Nacional Medellin | 50% | 13 (7) | - | 50 |
America de Cali's Last Match – America de Cali vs Atletico Nacional Medellin
America de Cali will be hoping to return to winning ways after a 2-2 Colombia Cup draw with Atletico Nacional Medellin on November 16. In that match, America de Cali controlled 50% of possession and managed 11 shots on goal, with 6 hitting the target.
| Team | Possession | Shots (on target) | xG | Dangerous Attacks |
|---|---|---|---|---|
| America de Cali | 50% | 11 (6) | - | 84 |
| Atletico Nacional Medellin | 50% | 13 (7) | - | 50 |
Atletico Nacional Medellin vs America de Cali Stats
Key Stats
| Atletico Nacional Medellin | America de Cali | |
|---|---|---|
| 1.53 | Attacking Strength | 0.89 |
| 0.89 | Defence Strength | 0.8 |
| 2.3 | Points Per Game | 1.6 |
| 7/10 | WIN | 5/10 |
| 2/10 | DRAW | 1/10 |
| 3/10 | Clean Sheets | 3/10 |
| 7/10 | BTTS | 5/10 |
| 8/10 | Over 2.5 Goals | 7/10 |
| 2.4 | Average Scored | 1.6 |
Goals Scored vs Goals Conceded
Atletico Nacional Medellin are averaging 2.4 goals scored and 1.1 conceded per match, while America de Cali average 1.6 scored and 1.5 conceded per game.
Atletico Nacional Medellin 24-11
America de Cali 16-15
What are the odds for this match?
Atletico Nacional Medellin to win: @1.615
Draw: @3.7
America de Cali to win: @5.75
Over 2.5 Goals: @1.9
Lineups
Atletico Nacional Medellin (4-3-3) : Harlen Castillo, Camilo Candido, William Tesillo, Simon Garcia, Felipe Roman, Jorman Campuzano, Edwin Cardona, Mateus Uribe, Juan Manuel Rengifo Duque, Alfredo Morelos, Marino Hinestroza
America de Cali (4-4-2) : Jorge Soto, Andres Mosquera, Nicolas Hernandez, Jean Carlos Pestana, Marcos David Mina Lucumi, Jan Lucumi, Josen David Escobar del Duca, Rafael Carrascal, Tilman Palacios, Cristian Barrios, Adrian Ramos
Deportes Tolima 
Atletico Bucaramanga 
Independiente Santa Fe 
Fortaleza CEIF