Our Independiente Medellin vs Independiente Santa Fe Prediction: 1-2
Independiente Medellin vs Independiente Santa Fe in the Colombia Primera A is scheduled for an 01:10 GMT kick-off on Tuesday October 21, 2025. Our analysis suggests a 1-2 away win, but with both teams likely to get on the scoresheet, BTTS is also worth considering.
Our prediction is supported by key Independiente Medellin vs Independiente Santa Fe stats, including attacking and defensive strength, recent form and historical results — all detailed below.
→ View Today's Correct Score Predictions
Recent Form Insights
Independiente Medellin's Last Match – Independiente Santa Fe vs Independiente Medellin
Determined to maintain their recent success, Independiente Medellin must win following their 3-0 Colombia Cup victory against Independiente Santa Fe on October 2. In that match, Independiente Medellin recorded 50% possession, attempting 15 shots on goal, with 6 hitting the target.
| Team | Possession | Shots (on target) | xG | Dangerous Attacks |
|---|---|---|---|---|
 Independiente Santa Fe | 50% | 7 (2) | - | 77 |
 Independiente Medellin | 50% | 15 (6) | - | 72 |
Independiente Santa Fe's Last Match – Independiente Santa Fe vs Independiente Medellin
Independiente Santa Fe will look to get back on track following a 0-3 Colombia Cup loss against Independiente Medellin on October 2. In that match, Independiente Santa Fe recorded 50% possession, firing 7 shots at goal, with 2 on target.
| Team | Possession | Shots (on target) | xG | Dangerous Attacks |
|---|---|---|---|---|
| Independiente Santa Fe | 50% | 7 (2) | - | 77 |
| Independiente Medellin | 50% | 15 (6) | - | 72 |
Independiente Medellin vs Independiente Santa Fe Stats
Key Stats
| Independiente Medellin | Independiente Santa Fe | |
|---|---|---|
| 1.36 | Attacking Strength | 1.29 |
| 1.61 | Defence Strength | 0.83 |
| 2.1 | Points Per Game | 1.5 |
| 6/10 | WIN | 4/10 |
| 3/10 | DRAW | 3/10 |
| 2/10 | Clean Sheets | 3/10 |
| 8/10 | BTTS | 5/10 |
| 9/10 | Over 2.5 Goals | 5/10 |
| 2.2 | Average Scored | 1.4 |
Goals Scored vs Goals Conceded
Independiente Medellin are averaging 2.2 goals scored and 1.3 conceded per match, while Independiente Santa Fe average 1.4 scored and 1.1 conceded per game.
Atletico Bucaramanga 
Junior 
Fortaleza CEIF 
Independiente Medellin 
Atletico Nacional Medellin 
Deportes Tolima 
Independiente Santa Fe 
Deportivo Cali 
Llaneros 
Once Caldas 
Deportivo Pereira 
Union Magdalena 
America de Cali 
Aguilas Doradas 
Millonarios 
Envigado FC 
Deportivo Pasto 
Boyaca Chico 
La Equidad