Our Sao Paulo vs Atletico Nacional Medellin Prediction: 2-0
Sao Paulo vs Atletico Nacional Medellin in the Copa Libertadores is scheduled for an 00:30 GMT kick-off on Wednesday August 20, 2025. A tightly contested match is expected, but Atletico Nacional Medellin’s ability to capitalize on key moments could secure them a 0-1 win over Sao Paulo.
This Sao Paulo vs Atletico Nacional Medellin prediction is backed by a deep dive into both teams' recent performances, key stats and head-to-head history — all of which you'll find detailed below to help you make an informed betting decision.
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Recent Form Insights
Sao Paulo's Last Match – Sport Recife vs Sao Paulo
Sao Paulo will look to build on their last result following a 2-2 Brazil Serie A stalemate against Sport Recife on August 16. In that match, Sao Paulo had 67% possession and 11 attempts at goal, with 8 on target.
| Team | Possession | Shots (on target) | xG | Dangerous Attacks |
|---|---|---|---|---|
 Sport Recife | 33% | 7 (5) | 0.79 | 42 |
 Sao Paulo | 67% | 11 (8) | 1.35 | 48 |
Atletico Nacional Medellin's Last Match – Atletico Nacional Medellin vs Fortaleza CEIF
Atletico Nacional Medellin will aim to turn their fortunes around after a 2-2 Colombia Primera A draw with Fortaleza CEIF on August 17. In that match, Atletico Nacional Medellin saw 62% of the ball and created 12 goal attempts, with 5 on target.
| Team | Possession | Shots (on target) | xG | Dangerous Attacks |
|---|---|---|---|---|
 Atletico Nacional Medellin | 62% | 12 (5) | 1.07 | 34 |
 Fortaleza CEIF | 38% | 10 (6) | 0.7 | 26 |
Sao Paulo vs Atletico Nacional Medellin Stats
Key Stats
| Sao Paulo | Atletico Nacional Medellin | |
|---|---|---|
| 1 | Attacking Strength | 0.77 |
| 0.66 | Defence Strength | 1.26 |
| 2.1 | Points Per Game | 1.9 |
| 6/10 | WIN | 5/10 |
| 3/10 | DRAW | 4/10 |
| 4/10 | Clean Sheets | 5/10 |
| 5/10 | BTTS | 5/10 |
| 5/10 | Over 2.5 Goals | 6/10 |
| 1.6 | Average Scored | 1.7 |
Goals Scored vs Goals Conceded
Sao Paulo are averaging 1.6 goals scored and 0.8 conceded per match, while Atletico Nacional Medellin average 1.7 scored and 0.7 conceded per game.
Sao Paulo 16-8
Atletico Nacional Medellin 17-7
What are the odds for this match?
Sao Paulo to win: @1.909
Draw: @3.25
Atletico Nacional Medellin to win: @4.5
Velez Sarsfield 
Penarol 
Olimpia Asuncion