Our Leon vs Santos Laguna Prediction: 3-1
Leon vs Santos Laguna in the Mexico Liga MX is scheduled for an 01:00 GMT kick-off on Sunday February 22, 2026. We’re backing a 3-1 home victory, but with both teams creating plenty of chances, over 2.5 goals is another strong betting option.
This Leon vs Santos Laguna prediction is backed by a deep dive into both teams' recent performances, key stats and head-to-head history — all of which you'll find detailed below to help you make an informed betting decision.
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Recent Form Insights
Leon's Last Match – Monterrey vs Leon
Leon will be looking to bounce back after a 0-1 Mexico Liga MX defeat against Monterrey on February 15. In that match, Leon had 44% possession and 4 attempts at goal, with 2 on target.
| Team | Possession | Shots (on target) | xG | Dangerous Attacks |
|---|---|---|---|---|
 Monterrey | 56% | 13 (5) | 1.38 | 39 |
 Leon | 44% | 4 (2) | 0.55 | 27 |
Santos Laguna's Last Match – Santos Laguna vs Mazatlan FC
Santos Laguna will be eager to respond after suffering a 1-2 Mexico Liga MX defeat at the hands of Mazatlan FC on February 15.
Leon vs Santos Laguna Stats
Key Stats
| Leon | Santos Laguna | |
|---|---|---|
| 0.91 | Attacking Strength | 0.83 |
| 1.32 | Defence Strength | 1.76 |
| 0.5 | Points Per Game | 0.8 |
| 1/10 | WIN | 2/10 |
| 2/10 | DRAW | 2/10 |
| 0/10 | Clean Sheets | 1/10 |
| 6/10 | BTTS | 8/10 |
| 4/10 | Over 2.5 Goals | 9/10 |
| 0.7 | Average Scored | 1.3 |
Goals Scored vs Goals Conceded
Leon are averaging 0.7 goals scored and 1.6 conceded per match, while Santos Laguna average 1.3 scored and 2.6 conceded per game.
Leon 7-16
Santos Laguna 13-26
What are the odds for this match?
Leon to win: @1.615
Draw: @4.2
Santos Laguna to win: @5
Lineups
Leon (4-3-3) : Jordan Javier García Bonnet, Bryan Colula, Sebastian Vegas, Stiven Barreiro, Salvador Reyes, Ivan Moreno, Rodrigo Echeverria, Daniel Arcila, Juan Dominguez, Diber Cambindo, Javier Nicolas Vallejo
Santos Laguna (4-2-3-1) : Carlos Acevedo, Kevin Picon, Kevin Balanta, Bruno Amione, Emanuel Echeverria, Carlos Gruezo, Aldo Lopez, Kevin Palacios, Ezequiel Bullaude, Cristian Dajome, Lucas Di Yorio