Leon vs Santos Laguna Correct Score Prediction: Team Stats, H2H & Betting Insights

Our Leon vs Santos Laguna Prediction: 3-1

Leon vs Santos Laguna in the Mexico Liga MX is scheduled for an 01:00 GMT kick-off on Sunday February 22, 2026. We’re backing a 3-1 home victory, but with both teams creating plenty of chances, over 2.5 goals is another strong betting option.

This Leon vs Santos Laguna prediction is backed by a deep dive into both teams' recent performances, key stats and head-to-head history — all of which you'll find detailed below to help you make an informed betting decision.

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Recent Form Insights

Leon's Last Match – Monterrey vs Leon

Leon will be looking to bounce back after a 0-1 Mexico Liga MX defeat against Monterrey on February 15. In that match, Leon had 44% possession and 4 attempts at goal, with 2 on target.

Team	Possession	Shots (on target)	xG	Dangerous Attacks
Monterrey	56%	13 (5)	1.38	39
Leon	44%	4 (2)	0.55	27

Santos Laguna's Last Match – Santos Laguna vs Mazatlan FC

Santos Laguna will be eager to respond after suffering a 1-2 Mexico Liga MX defeat at the hands of Mazatlan FC on February 15.

Leon vs Santos Laguna Stats

Key Stats

Goals Scored vs Goals Conceded

Leon are averaging 0.7 goals scored and 1.6 conceded per match, while Santos Laguna average 1.3 scored and 2.6 conceded per game.

What are the odds for this match?

Leon to win: @1.615

Draw: @4.2

Santos Laguna to win: @5

Lineups

Leon (4-3-3) : Jordan Javier García Bonnet, Bryan Colula, Sebastian Vegas, Stiven Barreiro, Salvador Reyes, Ivan Moreno, Rodrigo Echeverria, Daniel Arcila, Juan Dominguez, Diber Cambindo, Javier Nicolas Vallejo

Santos Laguna (4-2-3-1) : Carlos Acevedo, Kevin Picon, Kevin Balanta, Bruno Amione, Emanuel Echeverria, Carlos Gruezo, Aldo Lopez, Kevin Palacios, Ezequiel Bullaude, Cristian Dajome, Lucas Di Yorio

Leon Fixtures

Santos Laguna Fixtures