Our Santos Laguna vs Atletico San Luis Prediction: 2-2
Santos Laguna vs Atletico San Luis in the Mexico Liga MX is scheduled for an 23:00 GMT kick-off on Sunday September 21, 2025. A 2-2 result is our main prediction, but with both teams likely to score, BTTS is another strong betting choice.
This Santos Laguna vs Atletico San Luis prediction is backed by a deep dive into both teams' recent performances, key stats and head-to-head history — all of which you'll find detailed below to help you make an informed betting decision.
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Recent Form Insights
Santos Laguna's Last Match – Atlas vs Santos Laguna
Santos Laguna will be determined to find a winning touch after a 2-2 Mexico Liga MX draw against Atlas on September 14. In that match, Santos Laguna controlled 64% of possession and managed 13 shots on goal, with 9 hitting the target.
| Team | Possession | Shots (on target) | xG | Dangerous Attacks |
|---|---|---|---|---|
 Atlas | 36% | 5 (3) | 0.39 | 31 |
 Santos Laguna | 64% | 13 (9) | 1.37 | 54 |
Atletico San Luis's Last Match – Atletico San Luis vs Tijuana
Atletico San Luis must win as they look to rediscover their winning form following a 1-1 Mexico Liga MX draw against Tijuana on September 15. In that match, Atletico San Luis recorded 49% possession, attempting 3 shots on goal, with 3 hitting the target.
| Team | Possession | Shots (on target) | xG | Dangerous Attacks |
|---|---|---|---|---|
 Atletico San Luis | 49% | 3 (3) | 0.89 | 26 |
 Tijuana | 51% | 5 (6) | 0.84 | 53 |
Santos Laguna vs Atletico San Luis Stats
Key Stats
| Santos Laguna | Atletico San Luis | |
|---|---|---|
| 0.82 | Attacking Strength | 1.12 |
| 1.28 | Defence Strength | 1.32 |
| 0.4 | Points Per Game | 0.8 |
| 1/10 | WIN | 2/10 |
| 1/10 | DRAW | 2/10 |
| 1/10 | Clean Sheets | 2/10 |
| 6/10 | BTTS | 6/10 |
| 7/10 | Over 2.5 Goals | 6/10 |
| 1 | Average Scored | 1.4 |
Goals Scored vs Goals Conceded
Santos Laguna are averaging 1.0 goals scored and 2.1 conceded per match, while Atletico San Luis average 1.4 scored and 2.0 conceded per game.
Santos Laguna 10-21
Atletico San Luis 14-20
What are the odds for this match?
Santos Laguna to win: @2.45
Draw: @3.6
Atletico San Luis to win: @2.7
Over 2.5 Goals: @1.8
Lineups
Santos Laguna (4-3-3) : Carlos Acevedo, Jose Abella, Haret Ortega, Kevin Balanta, Bruno Amione, Aldo Lopez, Javier Guemez, Kevin Palacios, Cristian Dajome, Bruno Barticciotto, Fran Villalba
Atletico San Luis (4-2-3-1) : Andres Sanchez, Roman Torres Acosta, Eduardo Aguila, Robson Bambu, Juan Sanabria, Oscar Macias, Sebastien Salles-Lamonge, Miguel Garcia, Sebastian Bouquet Perez, Benjamin Galdames, Joao Pedro Galvao
Toluca 
Club America 
Monterrey 
Cruz Azul 
Tigres UANL 
Tijuana 
Pachuca 
Juarez FC 
Chivas Guadalajara 
Unam Pumas 
Atlas 
Leon 
Mazatlan FC 
Queretaro 
Atletico San Luis 
Santos Laguna 
Necaxa 
Puebla