Our Monterrey vs Santos Laguna Prediction: 3-1
Monterrey vs Santos Laguna in the Mexico Liga MX is scheduled for an 01:00 GMT kick-off on Sunday September 28, 2025. A 3-1 win for the home side is our main prediction, though over 2.5 goals looks like a valuable bet given both teams’ attacking tendencies.
This Monterrey vs Santos Laguna prediction is backed by a deep dive into both teams' recent performances, key stats and head-to-head history — all of which you'll find detailed below to help you make an informed betting decision.
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Recent Form Insights
Monterrey's Last Match – Toluca vs Monterrey
Monterrey must win to recover from their recent 2-6 Mexico Liga MX defeat against Toluca on September 25 and regain momentum. In that match, Monterrey saw 53% of the ball and created 8 goal attempts, with 7 on target.
| Team | Possession | Shots (on target) | xG | Dangerous Attacks |
|---|---|---|---|---|
 Toluca | 47% | 11 (13) | 3.38 | 0 |
 Monterrey | 53% | 8 (7) | 2.55 | 0 |
Santos Laguna's Last Match – Santos Laguna vs Tijuana
Santos Laguna must win to build on their momentum after securing a hard-fought 1-0 Mexico Liga MX victory over Tijuana in their last outing. In that match, Santos Laguna recorded 47% possession, firing 11 shots at goal, with 6 on target.
| Team | Possession | Shots (on target) | xG | Dangerous Attacks |
|---|---|---|---|---|
 Santos Laguna | 47% | 11 (6) | 1.46 | 28 |
 Tijuana | 53% | 9 (1) | 2.02 | 48 |
Monterrey vs Santos Laguna Stats
Key Stats
| Monterrey | Santos Laguna | |
|---|---|---|
| 1.36 | Attacking Strength | 0.87 |
| 0.95 | Defence Strength | 1.42 |
| 1.7 | Points Per Game | 0.7 |
| 5/10 | WIN | 2/10 |
| 2/10 | DRAW | 1/10 |
| 2/10 | Clean Sheets | 2/10 |
| 7/10 | BTTS | 6/10 |
| 7/10 | Over 2.5 Goals | 7/10 |
| 2.1 | Average Scored | 1 |
Goals Scored vs Goals Conceded
Monterrey are averaging 2.1 goals scored and 1.9 conceded per match, while Santos Laguna average 1.0 scored and 2.0 conceded per game.
Monterrey 21-19
Santos Laguna 10-20
What are the odds for this match?
Monterrey to win: @1.333
Draw: @5.75
Santos Laguna to win: @7
Lineups
Monterrey (4-4-2) : Santiago Mele, Ricardo Chavez, Sergio Ramos, Fidel Ambriz, Gerardo Arteaga, Oliver Torres, Stefan Medina, Jesus Corona, Anthony Martial, German Berterame, Lucas Ocampos
Santos Laguna (4-4-2) : Carlos Acevedo, Bruno Amione, Jonathan Perez, Aldo Lopez, Jose Abella, Javier Guemez, Kevin Balanta, Cristian Dajome, Jesus Ocejo, Ramiro Sordo, Salvador Mariscal
Toluca 
Tigres UANL 
Cruz Azul 
Club America 
Monterrey 
Chivas Guadalajara 
Tijuana 
Juarez FC 
Pachuca 
Unam Pumas 
Santos Laguna 
Queretaro 
Necaxa 
Atlas 
Atletico San Luis 
Mazatlan FC 
Leon 
Puebla